DESCRIPTION OF CRP LEVELS IN ALLERGIC MICE AFTER KETEPENG LEAF INFUSA TREATMENT

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Adi Firmansyah
I Gede Andika Sukarya
Suryanata Kesuma

Abstract

Allergy is a hypersensitivity reaction that arises due to exposure to allergens. Allergens will bind to IgE attached to mast cells and cause these cells to release various chemicals in the blood. One of them is, histamine which causes most allergic reactions. Allergic reactions can cause inflammation or inflammation. Inflammatory stimulation will later stimulate the release of C-Reactive Protein (CRP). CRP is an inflammatory maker that is produced and synthesized in the liver. Ketepeng leaf infusion has the potential to stimulate an immune response because it contains chemical compounds, namely alkaloids, saponins, flavonoids, tannins, and anthracino. Flavonoids contained in this plant function to provide anti-inflammatory, antiallergic, antioxidant and antifungal effects. The purpose of this study was to determine the effectiveness of ketepeng leaves (Cassia alata L) by examining CRP (C-Reactive Protein) levels in Ovalbumin-allergic mice (Mus musculus). This type of research is Univariate, which is a method for making an overview of the state of the object being examined through data or sampling samples. The results of this study found that in group 2 after being given ovalbumin, CRP levels increased by 181.33 mg/L and in group 3, after being given ketepeng leaf infusion, CRP levels decreased by 48 mg/L. The conclusion of this study is that ketepeng leaf infusion can reduce CRP levels in mice with ovalbumin allergy and there is an effect of increasing CRP levels in mice given ovalbumin of 181.33 mg/L and a decrease in CRP levels after the treatment of ketepeng leaf infusion of 48 mg/L .

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AACG Meryend Putri Gama, subakir, S. (2011). Pebandingan Ekstrak Daun Ketepeng Cina (Cessia alata, linn) Dengan Ketokenzol 2% Dalam Menghambat Pertumbuhan Malassezia furfur Pada Pityriasis versicolor Secara Invitro. 1–12.
Aldi, Y. M. Y. A. Z. R. (2015). Aktivitas Ketepeng Cina (Cassia alata L.) sebagai Anti Anafilaksis Kutan Aktif pada Mencit Putih Jantan.
Artanti, Mathlail Fajri, Nurul Marfu’ah, L. O. (2018). Aktifitas antifungi daun ketepeng cina (Cassia alata L.) fraksi etanol, n-heksan, dan kloroform terhadap jamur Microsporium canis. Pharmaceutical Journal of Islamic Pharmacy, 2(1), 28.
Asmah, N., Halimatussakdiah, H., & Amna, U. (2020). Analisa Kandungan Senyawa Metabolit Sekunder Ekstrak Daun Ketepeng Cina (Cassia alata L.) dari Bireum Bayeun, Aceh Timur. QUIMICA: Jurnal Kimia Sains Dan Terapan, 2(2), 7–10.


Caubet, J. C., Bencharitiwong, R., Moshier, E., Godbold, J. H., Sampson, H. A., & Nowak-Wegrzyn, A. (2012). Significance of ovomucoid- and ovalbumin-specific IgE/IgG 4 ratios in egg allergy. Journal of Allergy and Clinical Immunology, 129(3), 739–747.
Dewi, H. N. C., Paruntu, M. E., & Tiho, M. (2016). Gambaran kadar C-reactive protein (CRP) serum pada perokok aktif usia >40 tahun. Jurnal E-Biomedik, 4(2), 2–5.
Dewi, R. K. (2011). Pemeriksaan C-reactive protein ( CRP ) CRP.
Doumatey, A. P., Chen, G., Ayele, F. T., Zhou, J., Erdos, M., Shriner, D., Huang, H., Adeleye, J., Balogun, W., Fasanmade, O., Johnson, T., Oli, J., Okafor, G., Amoah, A., Eghan, B. A., Agyenim-Boateng, K., Acheampong, J., Adebamowo, C., Gerry, N. P., Rotimi, C. N. (2012). C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. Human Molecular Genetics, 21(13), 3063–3072.
Hartanto, E. (2017). Potensi Kunyit putih (Curcuma zedoaria) Terhadap Kadar C-Reactive Protein (CRP) Pada Mencit Yang Diinfeksi Bakteri Escherichia coli. Jurnal poltekkeks kemenkes surabaya, 141-147.
Hasanah, A. (2017). Efek Jus Bawang Bombay (Allium Cepa Linn.) Terhadap Motilitas Spermatozoa Mencit Yang Diinduksi Streptozotocin (Stz). Saintika Medika, 11(2), 92.
Hasanah A. N., Fikri N., Ellin F., dan Ade Z. Analisis Kandungan Minyak Atsiri dan Uji Aktivitas Antiinflamsi Ekstrak Rimpang Kencur (Kaempferiae galanga L.). Jurnal Matematika & Sains. 2011;16(3):147-152.
Hidayati NA, Listyawati S. & Setyawan D. Kandungan Kimia dan Uji Antiinflamasi Ekstrak Etanol Lantana camara L. pada Tikus Putih (Rattus norvegicus L.) Jantan. Bioteknologi, 2005; 5 (1): 10-17
Hikmah, Nuzulul dan I Dewa Ayu Ratna Deawanti. (2015). Seputar Reaksi Hipersensitivitas (Alergi). Jurnal Universitas Jember, 7(2), 109-112.
Hutagalung JS., Prasetyo R. Heru, T. E. A. (2012). Pulmonary Cryptosporidiosrs in HIV and AIDS. Indonesian Journal of Clinical Pathology and Medical Laboratory, 19(1), 1–4.
Lestari, E., & Santoso, Y. (2016). Pengaruh Suplemen Vitamin D Terhadap Jumlah Eosinofil Jaringan Paru Penderita Alergi Studi Eksperimental Pada Mencit Balb/C Yang Diinduksi Ovalbumin. Jurnal Kedokteran Diponegoro, 5(4), 761–771.
Megawati, simanullang. (2018). Gambara C-Reactive Protein (CRP) pada mahasiswa mahasiswi yang obesitas di poltekkes jurusan analis kesehatan medan. Photosynthetica, 2(1), 1–13.
Mohammed, M. S. et al. (2014) ‘Secondary metabolites as anti-inflammatory agents’, The Journal of Phytopharmacology, 3(4), pp. 275–285. Available at: www.phytopharmajournal.com.
Nijveldt, R.J., Nood, E.V., Hoorn, D.E.C.,Boelens P.G., Norren K.V., danLeeuwen, P.A.M. 2001. Flavonoids: A Review of Probable mechanismsofAction and Potential Application. AmJClin Nutr. 74 : 418-425.
Ningrum, H., Irawan, E., & Lubis, M. R. (2021). Implementasi Metode K-Medoids Clustering Dalam Pengelompokan Data Penyakit Alergi Pada Anak. Jurasik (Jurnal Riset Sistem Informasi Dan Teknik Informatika), 6(1), 130.
Nugraha, A., & Anwar, D. (2015). Manfaat Daun Ketepeng Cina ( Cassia alata L . ) sebagai Antifungi pada Tinea Pedis Benefits Ketepeng Cina ( Cassia alata L .) as an Antifungal on Tinea Pedis.
Nugroho, R. A. (2018). Mengenal Mencit Sebagai Hewan Laboratorium. In Mulawarman University Press (Vol. 4, Issue 1).
Panggabean, D. (2020). Karya Tulis Ilmiah Gambaran C- Reactive Protein ( Crp ) Pada Perokok Aktif Rika Ritami Sipahutar Politeknik Kesehatan Kemenkes Medan Jurusan Teknologi Laboratorium Medis Tahun 2020.
Prasetyo, Y. S. dwi. (2022). Efek pemberian ekstrak daun ketepeng (Cassia alata L) terhadap kadar CRP (C-Reactive Protein) pada mencit (Mus musculus alergi yang di induksi dengan ovalbumin.
Sayuti, N. A. (2015). Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ketepeng Cina (Cassia alata L.). Jurnal Kefarmasian Indonesia, 5(2), 74–82.
Sembiring, B. D. (2021). C-Reaktive Protein. Majalah Ilmiah METHODA, 11(1), 35–39.
Shin, H. S., See, H. J., Jung, S. Y., Choi, D. W., Kwon, D. A., Bae, M. J., Sung, K. S., & Shon, D. H. (2015). Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper T cells (Th1/Th2) balance in a mouse model of food allergy. Journal of Ethnopharmacology, 175, 21–29.
Sholeha, T. U., Ramadhian, M. R., Warganegara, E., Mayasari, D., & Putri, D. R. (2018). Perbandingan efektivitas terbinafin dengan ekstrak daun ketepeng cina ( Cassia alata . l ) terhadap pertumbuhan jamur ( Malassezia furfur ) sebagai etiologi pityriasis versicolor. Journal Agromedicine Unila, 5(2), 567–573.
Utama, I. M. G. D. L. (2016). Uji Diagnostik C-Reactive Protein, Leukosit, Nilai Total Neutrofil dan Suhu Anak Deman dengan Penyebab yang Tidak Diketahui. Sari Pediatri, 13(6), 412.
Widyasari, N. (2017). Hubungan Karakteristik Responden Dengan Risiko Diabetes Melitus Dan Dislipidemia Kelurahan Tanah Kalikedinding. Jurnal Unair, 5(1), 131–141.
Yusrita, E. ; N. (2021). Gambaran C-Reactive Protein (CRP) pada lansia dengan kadar asam urat tinggi di sekaladi hilir kecamatan tanah putih kabupaten rokan hilir. Jurnal sains dan Teknologi Laboratorium Medik.